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KMID : 0352720150390040376
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Journal of Ginseng Research
2015 Volume.39 No. 4 p.376 ~ p.383
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Protective effect of wild ginseng cambial meristematic cells on ?-galactosamine-induced hepatotoxicity in rats
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Kim Seok-Joo
Choi Hyo-Sun
Cho Hong-Ik
Jin Young-Woo
Lee Eun-Kyong
Ahn Jeung-Youb
Lee Sun-Mee
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Abstract
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Background: Panax ginseng has a wide range of biological activities including anti-inflammatory, antioxidant, and immunomodulatory functions. Wild ginseng cambial meristematic cells (CMCs) were obtained from P. ginseng cambium. This study examined the protective mechanism of wild ginseng CMCs against D-galactosamine (GalN)-induced liver injury. GalN, a well-known hepatotoxicant, causes severe hepatocellular inflammatory damage and clinical features similar to those of human viral hepatitis in experimental animals. Methods: Hepatotoxicity was induced in rats using GalN (700 mg/kg, i.p.). Wild ginseng CMCs was administered orally once a day for 2 wks, and then 2 h prior to and 6 h after GalN injection. Results: Wild ginseng CMCs attenuated the increase in serum aminotransferase activity that occurs 24 h after GalN injection. Wild ginseng CMCs also attenuated the GalN-induced increase in serum tumor necrosis factor-${\alpha}$ 수식 이미지, interleukin-6 level, and hepatic cyclooxygenase-2 protein and mRNA expression. Wild ginseng CMCs augmented the increase in serum interleukin -10 and hepatic heme oxygenase-1 protein and mRNA expression that was induced by GalN, inhibited the increase in the nuclear level of nuclear factor-kappa B, and enhanced the increase in NF-E2-related factor 2. Conclusion: Our findings suggest that wild ginseng CMCs protects liver against GalN-induced inflammation by suppressing proinflammatory mediators and enhancing production of anti-inflammatory mediators.
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KEYWORD
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D-galactosamine, heme oxygenase-1, hepatitis, Panax ginseng, wild ginseng cambial meristematic cells
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